RBF Symposium

February 2, 2015
9:00 hrs	Inauguration
9:30 hrs	Inaugural Address
		*Nuclear reprogramming and cell replacement prospects.* Sir John Gurdon, DPhil DSc FRS 2012 Nobel Prize in Medicine Distinguished Group Leader in the Wellcome Trust / CRUK Gurdon Institute, Cambridge, UK
11:00 hrs	*Exhibition & Poster Session Inauguration*

Session I
11:45 hrs	*Introductory Remarks:* Richard DiMarchi, Ph.D. 2014 inductee to the National Inventors Hall of Fame Standiford H. Cox Distinguished Professor of Chemistry Linda & Jack Gill Chair in Biomolecular Sciences Indiana University
Chairpersons: • T. K. Chakraborty, Ph.D., Professor, Department of Organic Chemistry, Indian Institute of Science, Bangalore • Dhavalkumar D. Patel, M.D., Ph.D., Head, Novartis Institute of Biomedical Research Europe, Basel, Switzerland
12:00 hrs		*Design of drugs to treat influenza A virus infections and tissue fibrosis.* Bill DeGrado, Ph.D. Professor, The DeGrado Laboratory Department of Pharmaceutical Chemistry University of California, San Francisco, USA
12:45 hrs		*Adapting Proteostasis to Ameliorate Disease Pharmacologically* Jeff Kelly, Ph.D Lita Annenberg Hazen Professor of Chemistry Chairman, Department of Molecular and Experimental Medicine The Kelly Group, The Scripps Research Insitute La Jolla, California, USA
13:30 hrs	Lunch
14:30 hrs		*Cell-penetrating Mini-proteins* Gregory L. Verdine, Ph.D Erving Professor of Chemistry Harvard Department of Stem Cell and Regenerative Biology Harvard University Cambridge, USA
15:00 hrs		*New drug discovery from natural products at CSIR-IIIM Jammu* Ram Vishwakarma, Director IIIM Jammu and CSIR-Central Drug Research Institute / Council of Scientific & Industrial Research, Lucknow, UP, India
15:30 hrs		*Design, Development and Clinical Evaluation of Ligand-Targeted Therapies and Imaging Agents* Phil Low, Ph.D Ralph C. Corley Distinguished Professor of Chemistry and Director of the Purdue Center for Drug Discovery—Biochemistry, USA
16:00 hrs	Tea Break
16:30 hrs		Butelase 1 for C-terninal-specific Ligation and Macrocyclization of Peptides and Proteins James P. Tam, Ph.D. Professor, Division of Structural Biology & Biochemistry School of Biological Sciences, Nanyang Technological University, Singapore
17:00 hrs		Chemical Biotechnology Applied to Metabolic Diseases Richard DiMarchi, Ph.D. Standiford H. Cox Distinguished Professor of Chemistry Linda & Jack Gill Chair in Biomolecular Sciences Indiana University
17:45 hrs	Panel Discussion

February 3, 2015
Session II
Chairpersons: • Dr. D. Ramaiah, F.A.Sc; Director, CSIR-North East Institute of Science and Technology (CSIR-NEIST) • Professor Alok Dhawan; Director, Institute of Life Sciences (ILS)
9:00 hrs		*Novel approaches to the prevention and treatment of type 2 diabetes* Matthias H. Tschöp, M.D, Ph.D Alexander-von-Humboldt Professor, Research Director, Helmholtz Diabetes Center Director, Institute for Diabetes and Obesity, Helmholtz Zentrum München Chair, Division of Metabolic Diseases, Department of Medicine, Technische Universität München
09:45 hrs		*A small antidiabetic molecule prevents lipid induced insulin resistance through PPARγ dependent and independent pathways* Prof. Samir Bhattacharya, Ph.D, FNA, FASc, FNASc (Former Director Indian Institute of Chemical Biology, Kolkata) Emeritus Professor, NASI Senior Scientist, School of Life Science, Visva-Bharati , Santiniketan CSIR-North-East Institute of Science and Technology, Jorhat
10:30 hrs	Tea Break & Poster Session
Chairpersons: • Dr. D T Mourya, Director, National Institute of Virology, Pune • Dr Reinhard Glueck, CSO, Zydus Vaccines
11:30 hrs		*TARGETING THE IL-17 PATHWAY IN AUTOIMMUNE DISEASES* Dhavalkumar D. Patel, M.D., Ph.D. Head, Novartis Institute of Biomedical Research Europe, Basel, Switzerland
12:15 hrs		*Challenges and Opportunities in Development of Innovative Vaccines for the 21st Century* Rahul Singhvi, ScD COO, Global Vaccine Business Unit Takeda Pharmaceuticals, Inc. USA
13:00 hrs	Lunch
Session III
Chairpersons: • Charles F. Burant, M.D., Ph.D; Dr. Robert C. and Veronica Atkins Professor of Metabolism, The Burant Lab, University of Michigan Medical School, USA • Bill DeGrado, Ph.D.; Professor, The DeGrado Laboratory, Department of Pharmaceutical Chemistry, University of California, San Francisco
14:00 hrs		*In search of novel therapeutic approaches to improve insulin sensitivity* Philip Larsen, M.D, Ph.D Global Head of Diabetes Research and Translational Science, Sanofi Aventis
14.30 hrs		*Cardiovascular risk milieu in nonalcoholic fatty liver disease* Naga Chalasani, FACG Professor of Medicine, Professor of Cellular & Integrative Physiology Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, USA
15:00 hrs		*Saroglitazar: A novel PPAR α /γ agonist for NASH* Dr. Mukul Jain Senior V P, Pharmacology & Toxicology Zydus Research Center
15:30 hrs		*NASH/NAFLD biomarkers: Are we stuck with biopsies?* Dr. Marcus Hompesch President, CEO and Founder Profil Institute for Clinical Research, Inc, USA
16:00 hrs	Tea Break
16:30 hrs		*Diabetes: The Greatest Epidemic in the 21st Century?* Paul Zimmet, AO MD PhD FRACP FRCP FTSE Director Emeritus, Victor Smorgon Diabetes Centre, Baker IDI Heart and Diabetes Institute Adjunct Professor, Monash University Honorary President, International Diabetes Federation Chair, Programme Committee, World Diabetes Congress 2013 Melbourne, Australia
17:00 hrs		*Controlling the Tsunami:In our "Stars" or in our "Hands”* *Shaukat M. Sadikot* President-Elect, International Diabetes Federation 2013-2015, President of DiabetesIndia Consultant Endocrinology, Jaslok Hospital and Research Center
17:30 hrs		*Achieving better research and clinical outcomes in mHealth age* Viren Mehta, Ph.D. Chairman, Gather Health Limited Founder, Mehta Partners, LLC.
18:00-18:30 hrs	Panel Discussion

February 4, 2015
Session IV
Chairpersons: • Naga Chalasani, MD,FACG; Professor of Medicine, Professor of Cellular & Integrative Physiology, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, USA • Paul Zimmet, AO MD PhD FRACP FRCP FTSE; Director Emeritus, Victor Smorgon Diabetes Centre, Baker IDI Heart and Diabetes Institute, Australia
9:00 hrs		Discovering and Developing Drugs in India : A Scientific and Regulatory Perspective Dr. Y.K.Gupta, MBBS, MD,FAMS,FNASc,FIPS,FIAN Professor and Head, Pharmacology, AIIMS, India
09:30 hrs		*Reprogramming of PPARγ super-enhancers during browning of human adipocytes* Susanne Mandrup, Ph.D. Professor, Department of Biochemistry and Molecular Biology University of Southern Denmark
10:15 hrs		*Parenchymal-stromal Cell Interaction in Metabolic Diseases* Yoshihiro Ogawa, M.D., Ph.D. Professor and Chairman Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
11:15 hrs	Tea Break
11:30 hrs		*Innate Mechanisms of Metabolic Homeostasis* Ajay Chawla, M.D., Ph.D. Professor, Cardiovascular Research Institute, University of California, San Francisco,
12:15 hrs		*Multifaceted function of the transcription regulator PPAR* Walter Wahli, Ph.D Professor, Center for Integrative Genomics, University of Lausanne, Switzerland, Professor of Metabolic Disease, Lee Kong Chian School of Medicine, Imperial College London & Nanyang Technological University, Singapore General Hospital, Singapore
13:00 hrs	Lunch
Session V
Chairpersons: • Philip Larsen, MD, Ph.D; Global Head of Diabetes Research and Translational Science, Sanofi Aventis • Richard DiMarchi, Ph.D; Standiford H. Cox Distinguished Professor of Chemistry, Linda & Jack Gill Chair in Biomolecular Sciences, Indiana University, USA
14.00 hrs		*Non-HDL cholesterol in the management of CVD* Anil Bhansali, DM Head, Department of Endocrinology, PGIMER, Chandigarh, India
14:45 hrs		*Clinicians perspective into current and future therapies of type-2 diabetes mellitus* Shashank R. Joshi MBBS, MD, DM, FACP, FRCP, FACE Consulting Endocrinologist, Lilavati Hospital in Mumbai, India
	Tea Break
16:00 hrs		*Developing New Drugs for Cardiometabolic diseases* Rajendra Jani, Ph.D. Sr. VP, Clinical R & D, Zydus Cadila
16:45 hrs		Metabolism modulation by diet and drugs, insights into mechanisms of action by metabolomics profiling Charles F. Burant, M.D., Ph.D Dr. Robert C. and Veronica Atkins Professor of Metabolism, The Burant Lab University of Michigan Medical School, USA
17:30 hrs	Best Poster Awards
18:00 hrs	Vote of Thanks